About Lexapro

Lexapro drug interactions

Lexapro interactions

Lexapro may be milder in terms of side effects, but there are still a number of things which you should avoid over the duration of your prescription.

If you are or are intending to take any of these things, you should consult your physician first as dosages may have to be adjusted so that medications don’t mix poorly.

Failure to exercise care in your medications can lead to side effects that range from annoying to deadly, so it’s important to know how Lexapro and other things will interact with each other.

The only non-medical substance you should watch with Lexapro is alcohol. Although you can have very small amounts with little to worry about, larger amounts of alcohol can have adverse effects on your psyche.

Alcohol is a depressant and so will negate the good of Lexapro or make your depression worsen. If you are drinking and taking Lexapro at the same time, it’s time to quit drinking or at least greatly reduce the amounts you ingest so that the drug can do it’s work unimpeded.

There are a number of drugs however that you should be careful of when you are on Lexapro and some of them are detailed below. These include very common things that you might take as a matter of course that could cause problems when combined with Lexapro. Aspirin.

Aspirin, Advil, Tylonol, these can all cause problems in that taking them alongside Lexapro can increase the risk of stomach bleeding. Ask your doctor what dosages are safe to take of these painkillers. Other drugs that can cause problems with stomach bleeding include NSAIDs.


Taking tagamet alongside Lexapro can actually increase the levels of Lexapro in your bloodstream which can increase the chances of having side effects that will be more difficult to manage.


Lexapro and Zyvox do not get along in the human body. Taking the two together can give you Serotonin Syndrome, a dangerous condition that includes confusion, hallucinations, diarrhea, faintness, fever, sweating, spasms, and difficulty walking. Other drugs that when mixed with Lexapro can cause Serotonin Syndrome are Lithium, any SSRI or SNRI antidepressants, St. John’s Wart, Ultram, Triptans and Tryptophan.

Monoamine Oxidase Inhibitors

Never take MOIs and Lexapro together and in fact, if you were on one and switching to the other, wait at least two weeks between quitting the old prescription and starting the new one.

The combination of MOIs and Lexapro can cause life threatening side effects and are very dangerous. It’s best to avoid any chance of mixing the two altogether so make certain to tell your doctor of all of the medications you are taking in case any of them are MOIs.


Taking Orap and Lexapro is dangerous because the combination can cause irregular heart beats called arrhythmia which can be very dangerous, especially for the elderly or anyone with a heart condition. Avoid taking Orap and Lexapro together.

It is very important to tell your healthcare provider of all of the drugs you are taking and even whether you routinely take things like aspirin.

Not all of the drugs which can have a bad interaction with Lexapro are known and so it is definitely better safe than sorry.

Your doctor will adjust or take out prescriptions of any other medications in order to allow Lexapro to do what it needs to do without any harm to you.

It is also important to tell your doctor if you have any uncomfortable side effects and to go in for emergency care if you suffer from things like faintness, sudden severe pains or stomach problems, or anything else that is unusual. This is very much for your own safety.